Immunotherapy in Autoimmune Type 1 Diabetes
نویسندگان
چکیده
منابع مشابه
Immunotherapy of type 1 diabetes: lessons for other autoimmune diseases
The nonobese diabetic (NOD) mouse is a well-recognised animal model of spontaneous autoimmune insulin-dependent diabetes mellitus. The disease is T-cell mediated, involving both CD4 and CD8 cells. Its progress is controlled by a variety of regulatory T cells. An unprecedented number of immunological treatments have been assessed in this mouse strain. This chapter systematically reviews most of ...
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Background: Type 1 diabetes mellitus (T1DM) as an autoimmune disorder is associated with other autoimmune diseases such as autoimmune thyroid (AIT) disease. The aim of this study was to determine the prevalence of AIT in children who were referred to Amirkola Endocrine Clinic (north of Iran). Methods: This cross-sectional study was carried out on 100 diabetic children aged 1-15 years during ...
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1 Immunology Unit, Pathology & Clinical Laboratory Medicine, King Fahad Medical City, Box 59046, Riyadh 11525, Saudi Arabia 2Laboratory of Immunoendocrinology, Institute of Pathology CHU-B23, University of Liege Center of Immunology (CIL), 4000 Liege-Sart Tilman, Belgium 3Department of Pathology and Immunology, Diabetes Institute, Rangos Research Center, University of Pittsburgh School of Medic...
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Immunotherapy targeting T-cell regulatory molecules is highly effective in multiple cancers refractory to standard chemotherapies. However, blocking inhibitory molecules on activated T cells not only increases tumor cell destruction but also can breach tolerance, enabling pathological T cells to react with self-antigens. Indeed, autoimmune endocrinopathies, including hypophysitis, hypopituitari...
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OBJECTIVE Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes. RESEARCH DESIGN AND METHODS To accomplish this, we studied whether LADA shares variation in...
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ژورنال
عنوان ژورنال: The Review of Diabetic Studies
سال: 2012
ISSN: 1613-6071,1614-0575
DOI: 10.1900/rds.2012.9.68